王宇彤

发布者:花文婷发布时间:2022-09-29浏览次数:3630

职称:副教授   E-mailwangyutong@njucm.edu.cn    主要研究方向:药物的新剂型与新制剂。


1)膜类载体递药系统的构建与机制研究

2)功能性短肽的设计、合成及其在现代药物制剂中的应用探索

3)新型智能微球,中药新制剂的产品研发。

 

个人简介

中国药科大学药剂学博士,从事药物新剂型开发及机制研究工作。近年主持国家自然科学基金1项,合作申请国家级自然科学项目1项,主持校级课题1项,参与国家级、省部级项目多项,申请专利2项,参编《药剂学实验》等教材。近五年以第一作者在Signal Transduction and Targeted TherapyTheranosticsCarbohydrate PolymersInternational Journal of NanomedicineSCI期刊上发表论文8篇,累积影响因子超过50,以第一/通讯作者发表中文核心期刊论文数篇。

 

承担的主要科研项目

1)国家自然科学基金青年项目(81803456),载药外泌体诱导生成多能干细胞用于治疗AD的研究,2019-012021-1221万元,结题,主持。

2)国家重点研发计划“中医药现代化研究”重点专项子课题(2018YFC1706905),多元微小丸及高载药量技术的中药释药系统设计关键技术研究,2018.122021.11结题,150万元,参与(技术骨干)。

3)国家自然科学基金地区科学基金(82060780),彝药美洲大蠊多肽原位驻留长效递释系统的构建及抗溃疡性结肠炎作用研究,2021.12024.1234万元,在研,参与。

 

代表性论文

(1) WangYutong #, Huang Jinyu #, et al. Extra virgin olive oil-based phospholipid complex/self-microemulsion enhances oral absorption of salvianolic acid B through inhibition of catechol-O-methyltransferase-mediated metabolism. International Journal of Pharmaceutics, 2022, 611: 121330.

(2) Chen Xiao#, Wang Yutong#, et al. Quantitative Chemical Proteomics Reveals Resveratrol Inhibition of A549 Cell Migration Through Binding Multiple Targets to Regulate Cytoskeletal Remodeling and Suppress EMT. Frontiers in pharmacology, 2021, 12: 636213.

(3) WangYutong #, Li Huaning #, et al. Mucoadhesive Nanocrystal-in-Microspheres with High Drug Loading Capacity for Bioavailability Enhancement of Silybin, Colloids and Surfaces B: Biointerfaces, 2021, 198: 111461.

(4) Chen Xiao#, Wang Yutong#, et al. Target identification of natural medicine with chemical proteomics approach: probe synthesis, target fishing and protein identification, Signal Transduction and Targeted Therapy, 2020, 5(1): 1-13.

(5) XuLiu #, Wang Yutong #, et al. Morphological transformation enhances Tumor Retention by Regulating the Self-assembly of Doxorubicin-peptide Conjugates, Theranostics, 2020, 10(18): 8162-8178.

(6) Wang Yutong #, Huang Liping #, et al. Electrostatic interactions between polyglutamic acid and polylysine yields stable polyion complex micelles for deoxypodophyllotoxin delivery, International Journal of Nanomedicine, 2017, 12: 7963-7977.

(7) Huang Liping #, Wang Yutong #, et al. Efficient delivery of paclitaxel into ASGPR over-expressed cancer cells using reversibly stabilized multifunctional pullulan nanoparticles. Carbohydrate polymers, 2017, 159: 178-187.

(8) WangYutong, Sun Ting, et al. Exenatide loaded PLGA microspheres for long-acting antidiabetic therapy: preparation, characterization, pharmacokinetics and pharmacodynamics, RSC Advances, 2016, 6(44): 37452-37462.


获得奖项与荣誉

2019年全国高校药学专业青年教师微课大赛一等奖

2021年江苏省高等学校科学技术研究成果奖二等奖(排名3

 


 

 




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